I give the slightest advantage to Isner as I believe his serve will be the difference maker.
Five Americans still remain in the field, including 2013 champion John Isner.
Another exciting match is a battle between 5th seed Federico Delbonis and unseeded Joao Sousa.
I like the top-ranked American to find a way to pull this one out.
Prediction: Isner in 3 Reilly Opelka vs Nick Kyrgios Head-to-head: Opelka 1-0 Kyrgios Fireworks will be had in what is a highly anticipated semifinal matchup between Opelka and Kyrgios.
Tommy Paul, Frances Tiafoe and Jenson Brooksby will all also be in action over the first two days of the tournament.