Eri Anime: My Hero Academia This fight requires quite a bit of head-cannon to claim Eri would win, but it is possible.
Sure, Rimuru can obviously kill Misogi with his flawless power.
His destructive output is formidable, but Rimuru has even stronger allies.
If you mess with them, they could retaliate in a big way.
As a slime, since his body is androgynous, anything he mimics takes on an androgynous form of the respective creatures, while still bearing huge resemblances to the individual creatures as well.
He was able to completely overwhelm with pure skill.